![]() After the chemoradiotherapy, the patient received four cycles of chemotherapy with irinotecan and cisplatin followed by six cycles of chemotherapy with paclitaxel and carboplatin. The serum level of SCCA was 1.2 ng/mL before chemoradiotherapy and 0.9 ng/mL after chemoradiotherapy. The serum level of CA125 decreased to 175 U/mL. Six weeks after beginning chemoradiotherapy, the left supraclavicular lymph node swelling disappeared, and computed tomography showed that the mediastinal lymph nodes had decreased in size. Three weeks after beginning chemoradiotherapy, the patient’s chest pain decreased in severity. The patient underwent chemoradiotherapy at 60 Gy/30 times for 6 weeks combined with an intravenous cisplatin drip weekly at 40 mg/m 2. She was a nonsmoker, and we considered the presence of human papilloma virus deoxyribonucleic acid (DNA) showed that the lymph node metastasis originated from cervical cancer the endoscopic examination for upper digestive tract was not scheduled. Biopsy of a left supraclavicular lymph node showed metastasis of squamous cell carcinoma, and type 18 human papillomavirus DNAs were detected by molecular biological analysis. She began to feel chest pain, and computed tomography showed swelling of left supraclavicular lymph nodes and mediastinal lymph nodes (Fig. Three years after the primary treatment, the patient’s CA125 serum level was elevated at 161 U/mL, and it further increased to 1260 U/mL 10 months later (Fig. Her high cancer antigen 125 (CA125) serum level of 79 U/mL before radical hysterectomy was considered to mainly originate from the endometrial cyst of the left ovary, and this level decreased to 5.1 U/mL after postoperative adjuvant chemotherapy. Her serum level of squamous cell carcinoma antigen (SCCA) was 5.6 ng/mL before radical hysterectomy and 0.9 ng/mL after postoperative adjuvant chemotherapy. Our experience suggests there are common factors between female reproductive organs and mediastinal lymph nodes, which may be related to the biological roles of CA125.Ī 27-year-old Japanese woman (gravida 0) underwent radical hysterectomy and left adnexectomy for stage 1b cervical cancer and an endometrial cyst of the left ovary, followed by four cycles of postoperative adjuvant chemotherapy with intravenous paclitaxel and carboplatin drips at Izumi City Hospital (the previous institution of Izumi General Hospital). Previous reports have described cases of lung cancer and pleural diseases characterized by an elevated serum CA125 concentration. Interaction of the CA125 epitope with the mesothelial lining may help tumor cells bind to the peritoneal cell membrane. CA125 is a cell membrane-spanning glycoprotein that serves as a biomarker for ovarian cancer and other tumors of female reproductive organs. We encountered a patient in whom metastasis of cervical squamous cell carcinoma to the lymph nodes was not reflected by the serum SCCA value but instead by an elevated serum cancer antigen 125 (CA125) value.ĬA125 was historically identified by a monoclonal antibody against an ovarian cancer cell line (OVCA433). Squamous cell carcinoma of the cervix is usually assessed with the biomarker squamous cell carcinoma antigen (SCCA), which reflects the tumor status. In this case, metastasis of cervical cancer to the mediastinal and supraclavicular lymph nodes was shown by the biomarker cancer antigen 125, which was not present in the original neoplasia. By contrast, cancer antigen 125 was distributed in the supraclavicular lymph node metastatic tissue but not in the original squamous cell cancer tissue of the cervix. ![]() Squamous cell carcinoma antigen was found to be distributed in both the squamous cell cancer tissue of the cervix and the supraclavicular lymph node metastatic tissue. After chemoradiotherapy and chemotherapy, the serum cancer antigen 125 concentration decreased to a normal value. We herein report a 30-year-old Japanese woman of postoperative metastasis of cervical squamous cell cancer to the mediastinal and supraclavicular lymph nodes as indicated by an elevated serum cancer antigen 125 concentration and not by the squamous cell carcinoma antigen value. The biomarker squamous cell carcinoma antigen is usually utilized for follow-up of squamous cell cancer of the cervix. In patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. ![]()
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